Anti-fibrotic effects of bone morphogenetic protein-7-modified bone marrow mesenchymal stem cells on silica-induced pulmonary fibrosis

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• 作者：Xiaoli Li¹ ; Guoliang An¹ ; Yan Wang ; Di Liang ; Zhonghui Zhu ; Ximeng Lian ; Piye Niu ; Caixia Guo ; Lin Tian ; ^{tian_lin@163.com}
• 关键词：BMP-7 ; bone morphogenetic protein-7 ; BMSCs ; bone marrow mesenchymal stem cells ; BMP-7-BMSCs ; BMSCs overexpress the BMP-7 gene by lentivirus transduction ; FN ; fibronectin ; TGF-β1 ; transforming growth factor beta 1 ; SP-C ; epithelial marker surfactant protein-C ; AQP-5 ; aquaporin-5 ; MSC ; mesenchymal stem cell ; BAL ; bronchoalveolar lavage ; Bcl-2 ; B-cell lymphoma-2 ; HO-1 ; heme oxygenase-1 ; GFP ; green fluorescent protein
• 刊名：Experimental and Molecular Pathology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：102
• 期：1
• 页码：70-77
• 全文大小：1648 K
• 卷排序：102

文摘

Bone marrow mesenchymal stem cells (BMSCs) can reduce pulmonary fibrosis induced by silica in rats. The anti-fibrotic role of BMSCs can be strengthened by bone morphogenetic protein-7 (BMP-7). Strategies incorporating genetic engineering and stem cell biology have a tremendous potential to treat silicosis.