Sortilin-related receptor CNS expressed 2 (SorCS2) is localized to Bunina bodies in amyotrophic lateral sclerosis
详细信息 查看全文
- 作者：Fumiaki Mori
- 关键词：Amyotrophic lateral sclerosis ; Bunina bodies ; Immunohistochemistry ; Sortilin-related receptor CNS expressed 2 ; Vacuolar protein sorting 10 family proteins
- 刊名：Neuroscience Letters
- 出版年：2015
- 出版时间：3 November 2015
- 年：2015
- 卷：608
- 期：Complete
- 页码：6-11
- 全文大小：2687 K
文摘
- •
- <p id="par0005">Amyotrophic lateral sclerosis (ALS) is one of the most devastating neurodegenerative disease.p>
- •
- <p id="par0010">ALS-specific Bunina bodies are immunoreactive for SorCS2, a member of vacuolar protein sorting 10 family proteins (VPS10Ps).p>
- •
- <p id="par0015">Immunoreativity for VPS10Ps, sortilin and SorLA, is decreased in anterior horn cells of ALS patients.p>
- •
- <p id="par0020">VPS10Ps may be involved in the pathomechanisms of ALS.p>