Analysis of inflammation-induced depression of home cage wheel running in rats reveals the difference between opioid antinociception and restoration of function
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- 作者：Ram Kandasamya ; ram_kandasamy@wsu.edu" class="auth_mail" title="E-mail the corresponding author ; Jonas J. Calsbeekb ; Michael M. Morgana ; b
- 关键词：Pain-depressed behavior ; Morphine ; Buprenorphine ; Sex differences ; Antinociception
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：502-507
- 全文大小：1350 K
文摘
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Home cage wheel running can be used to assess pain and opioid analgesia.
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Low doses of morphine reversed pain-depressed wheel running only.
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High doses of morphine reversed evoked hypersensitivity only.
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All buprenorphine doses depressed wheel running in all rats.
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Wheel running reveals limitations of opioids to restore normal activity.