A role for the mu opioid receptor in the antidepressant effects of buprenorphine

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• 作者：Shivon A. Robinson^a ; Rebecca L. Erickson^b ; Caroline A. Browne^a ; Irwin Lucki^a ; ^c ; ^{irwin.lucki@usuhs.edu}
• 关键词：Buprenorphine ; Antidepressant ; Endogenous opioid system ; Novelty-induced hypophagia
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：319
• 期：Complete
• 页码：96-103
• 全文大小：1666 K
• 卷排序：319

文摘

Oprm1−/− mice, but not Oprk1−/− mice, showed slower learning to approach palatable food. Oprm1−/− mice, but not Oprk1−/− mice, failed to respond to buprenorphine in the novelty-induced hypophagia test. Buprenorphine and cyprodime antagonized mu opioid receptors. Buprenorphine and cyprodime reduced approach latency in the novelty induced hypophagia test.