JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse
详细信息 查看全文
- 作者：Jamee M. Berg1 ; 2 ; 3 ; Changhoon Lee3 ; Leslie Chen3 ; Laurie Galvan4 ; Carlos Cepeda4 ; Jane Y. Chen4 ; Olga Peñ ; agarikano3 ; Jason L. Stein3 ; Alvin Li3 ; Asami Oguro-Ando3 ; Jeremy A. Miller3 ; Ajay A. Vashisht5 ; Mary E. Starks3 ; Elyse P. Kite3 ; Eric Tam3 ; Amos Gdalyahu2 ; 3 ; Noor B. Al-Sharif4 ; Zachary D. Burkett6 ; 7 ; Stephanie A. White6 ; 7 ; Scott C. Fears4 ; Michael S. Levine4 ; James A. Wohlschlegel5 ; Daniel H. Geschwind2 ; 3 ; 4 ; 8 ; dhg@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2015
- 出版时间：16 December 2015
- 年：2015
- 卷：88
- 期：6
- 页码：1173-1191
- 全文大小：5108 K
文摘
- •
JAKMIP1 is a novel component of an FMRP-associated RNP complex
- •
JAKMIP1 binds synaptic mRNAs and PSD proteins implicated in ASD
- •
JAKMIP1 regulates neuronal translation and glutamatergic signaling
- •
JAKMIP1 knockout results in core ASD behaviors in the mouse