Antitumor gemcitabine conjugated micelles from amphiphilic comb-like random copolymers
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- 作者：Jianfeng Wanga ; Xiaomin Zhangb ; Yixin Cena ; Xianfu Lina ; Qi Wua ; wuqi1000@163.com" class="auth_mail" title="E-mail the corresponding author ; llc123@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Comb-like copolymers ; Nanomicelles ; Gemcitabine ; PEG ; Antitumor activity
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：146
- 期：Complete
- 页码：707-715
- 全文大小：1802 K
文摘
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Novel comb-like amphiphilic random copolymers with PEG and gemcitabine side chains were prepared.
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These random copolymers can efficiently self-assemble into nanomicelles.
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PEGylated micelles had prolonged biologic half-life and improved pharmacokinetic behavior.
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PEGylated micelles showed significantly higher A549 tumor suppression rate.