Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice

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• 作者：Ana Carla Balthar Bandeira^a ; ^b ; Rafaella Cecí ; lia da Silva^b ; Joamyr Victor Rossoni Jú ; nior^a ; Vivian Paulino Figueiredo^a ; André ; Talvani^a ; Silvia Dantas Cangussú ; ^b ; Frank Silva Bezerra^a ; ^b ; Daniela Caldeira Costa^a ; ^b ; ^{dani.caldeiracosta@gmail.com}
• 关键词：Lycopene ; Acetaminophen ; Redox imbalance ; Inflammation ; C57BL/6 mice
• 刊名：Bioorganic & Medicinal Chemistry
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：25
• 期：3
• 页码：1057-1065
• 全文大小：1254 K
• 卷排序：25

文摘

Acetaminophen (APAP) is an antipyretic and analgesic drug that, in high doses, leads to severe liver injury and potentially death. Oxidative stress is an important event in APAP overdose. Researchers are looking for natural antioxidants with the potential to mitigate the harmful effects of reactive oxygen species in different models. Lycopene has been widely studied for its antioxidant properties. The aim of this study was to evaluate the antioxidant potential of lycopene pretreatment in APAP-induced liver injury in C57BL/6 mice. C57BL/6 male mice were divided into the following groups: control (C); sunflower oil (CO); acetaminophen 500 mg/kg (APAP); acetaminophen 500 mg/kg + lycopene 10 mg/kg (APAP + L10), and acetaminophen 500 mg/kg + lycopene 100 mg/kg (APAP + L100). Mice were pretreated with lycopene for 14 consecutive days prior to APAP overdose. Analyses of blood serum and livers were performed. Lycopene was able to improve redox imbalance, decrease thiobarbituric acid reactive species level, and increase CAT and GSH levels. In addition, it decreased the IL-1β expression and the activity of MMP-2. This study revealed that preventive lycopene consumption in C57BL/6 mice can attenuate the effects of APAP-induced liver injury. Furthermore, by improving the redox state, and thus indicating its potential antioxidant effect, lycopene was also shown to have an influence on inflammatory events.