Non-junctional E-Cadherin Clusters Regulate the Actomyosin Cortex in the C. elegans Zygote

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• 作者：Anup Padmanabhan¹ ; Hui Ting Ong¹ ; Ronen Zaidel-Bar¹ ; ² ; ³ ; ^{biezbr@nus.edu.sg}
• 关键词：cadherin ; myosin II ; actin cortex ; cytokinesis ; RHO ; non-junctional ; cluster ; HMR-1 ; NMY-2 ; C. elegans
• 刊名：Current Biology
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：27
• 期：1
• 页码：103-112
• 全文大小：4658 K
• 卷排序：27

文摘

Non-junctional E-cadherin clusters associate with cortical actin in C. elegans embryos E-cadherin clusters resist cortical flow and inhibit RhoA and myosin II localization E-cadherin depletion in C. elegans zygotes accelerates cytokinetic furrow ingression E-cadherin supports structural integrity of the cell cortex independent of cell adhesion