Activity of caffeic acid derivatives against Candida albicans biofilm

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• 作者：Daniela De Vita^a ; ^&dagger ; ; Laura Friggeri^a ; ^&dagger ; ; Felicia Diodata D&rsquo ; Auria^c ; Fabiana Pandolfi^a ; Francesco Piccoli^a ; Simona Panella^c ; Anna Teresa Palamara^c ; Giovanna Simonetti^c ; ^{giovanna.simonetti@uniroma1.it" class="auth_mail} ; Luigi Scipione^a ; ^{luigi.scipione@uniroma1.it" class="auth_mail} ; Roberto Di Santo^b ; Roberta Costi^b ; Silvano Tortorella^a
• 关键词：OCNYGKNIVPVPPX-HWKANZROSA-N ; QAIPRVGONGVQAS-DUXPYHPUSA-N ; WDKYDMULARNCIS-GQCTYLIASA-N ; BPJXSLLUNRTWHM-GQCTYLIASA-N ; HUBVPNVELDTWJF-GQCTYLIASA-N ; SEPKDTOLMAINTE-QHHAFSJGSA-N ; AVTLERVPYQTGGQ-RMKNXTFCSA-N ; LMETXPLAQOCORL-UHFFFAOYSA-N ; WYDVPXYGDFFEPG-UHFFFAOYSA-N
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：15 March, 2014
• 年：2014
• 卷：24
• 期：6
• 页码：1502-1505
• 全文大小：372 K

文摘

The aim of this study was to evaluate the caffeic acid (1) and ester derivatives (2-10) against Candida albicans biofilm and to investigate whether these compounds are able to inhibit the biofilm formation or destroy pre-formed biofilm.

Caffeic acid ester 7, cinnamic acid ester 8 and 3,4-dihydroxybenzoic acid ester 10 are more active than fluconazole, used as reference drug, both on biofilm in formation with MIC₅₀ values of 32, 32 and 16 渭g/mL, respectively, and in the early stage of biofilm formation (4 h) with MIC₅₀ values of 64, 32 and 64 渭g/mL, respectively. These esters result also more active than fluconazole on mature biofilm (24 h), especially 8 and 10 with MIC₅₀ values of 64 渭g/mL.