CpG ODN mimicking CpG rich region of myxosporean Myxobolus supamattayai stimulates innate immunity in Asian sea bass (Lates calcarifer) and defense against Streptococcus iniae
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- 作者：Kittichon U-taynapuna ; b ; Nion Chirapongsatonkula ; c ; Toshiaki Itamid ; Chutima Tantikittib ; chutima.t@psu.ac.th" class="auth_mail" title="E-mail the corresponding author
- 关键词：CpG ODN ; Lates calcarifer ; Immunostimulant ; Innate immunity ; Streptococcus iniae
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：58
- 期：Complete
- 页码：116-124
- 全文大小：1356 K
文摘
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First report of stimulatory effects of CpG ODN mimicking parasitic DNA.
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Parasitic CpG ODN 1013 induced defense responses as did ODN 1668 in Asia sea bass.
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Parasitic CpG ODN 1013 exhibited prolonged stimulatory effect in Asia sea bass.
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Parasitic CpG ODN 1013 induced defense-related genes and TLR 9 in Asia sea bass.
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Survival of CpG ODN 1013-treated fish was higher than that of PBS and ODN 1668.