Calcitriol-modulated human antibiotics: New pathophysiological aspects of vitamin D

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• 作者：Carlos Antonio Amado Diago^a ; ^{camado@humv.es" class="auth_mail" title="E-mail the corresponding author} ; Marí ; a Teresa Garcí ; a-Unzueta^b ; Marí ; a del Carmen Fariñ ; as^c ; Jose Antonio Amado^d
• 关键词：Cathelicidin ; Defensin ; Hepcidin ; Calcitriol ; Vitamin D
• 刊名：Endocrinología y Nutrición (English Edition)
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：63
• 期：2
• 页码：87-94
• 全文大小：908 K

文摘

Traditionally, calcitriol has been considered a calcium and phosphate regulating hormone, but has recently been shown to play a pivotal role in innate immunity. Many barrier and immune cells have membrane and intracellular receptors that recognize different microbial antigens. Activation of these receptors induces synthesis of 1α-hydroxylase, which acts on 25 hydroxyvitamin D to generate intracellular calcitriol. Calcitriol activates its receptor and enhances the synthesis of important human antibiotics like cathelicidin and β2-defensin while inhibiting hepcidin. These pluripotent peptides have an important role in innate immunity, and their regulation is abnormal in hypovitaminosis D. The literature on their secretion mechanisms, levels in different organic fluids, mechanism of action, and relationship with vitamin D is reviewed here.