Antidepressant actions of lateral habenula deep brain stimulation differentially correlate with CaMKII/GSK3/AMPK signaling locally and in the infralimbic cortex
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- 作者：Yesul Kima ; b ; Brooke Moratha ; Chunling Hua ; Linda K. Byrneb ; Shari L. Sutora ; Mark A. Fryea ; Susannah J. Tyea ; b ; c ; d ; tye.susannah@mayo.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：TRD ; Treatment resistant depression ; HPA ; Hypothalamic pituitary axis ; LHb ; Lateral habenula ; IL ; Infralimbic ; DBS ; Deep brain stimulation ; CaMKII ; Calcium/calmodulin dependent kinase type II ; GSK3 ; Gycogen synthase kinase 3 ; AMPK ; AMP-activated protein kinase
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：306
- 期：Complete
- 页码：170-177
- 全文大小：1621 K
文摘
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Animals treated with LHb DBS displayed antidepressant-like response in the FST.
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Greater phoshorylation of CaMKII and GSK3 in the LHb correlated with reduced immobility.
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Reduced phoshorylation of AMPK in the IL correlated with reduced immobility.
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LHb and IL share an inverse relationship with CaMKII, GSK3 and AMPK expression and they contribute to possible antidepressant actions of LHb DBS.