A scalable low-cost cGMP process for clinical grade production of the HIV inhibitor 5P12-RANTES in Pichia pastoris
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- 作者：Fabrice Cerinia ; Hubert Gaertnera ; Knut Maddenb ; Ilya Tolstorukovb ; c ; Scott Brownd ; Bram Laukense ; f ; Nico Callewaerte ; f ; Jay C. Harnerg ; Anna M. Oommeng ; John T. Harmsg ; Anthony R. Sumpg ; Robert C. Sealockg ; Dustin J. Petersong ; Scott K. Johnsong ; Stephan B. Abramsonh ; Michael Meagherg ; 1 ; Robin Offordi ; Oliver Hartleya ; i ; oliver.hartley@unige.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pichia ; Yeast ; Process development ; Chemokine ; HIV ; Microbicide ; CCR5 ; 5P12-RANTES ; Biopharmaceutical ; cGMP
- 刊名：Protein Expression and Purification
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：119
- 期：Complete
- 页码：1-10
- 全文大小：845 K
文摘
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New medicines are required to prevent the spread of HIV/AIDS in low-resource regions.
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5P12-RANTES, a chemokine analog, is a promising new candidate drug.
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We describe a process for producing clinical grade cGMP 5P12-RANTES in Pichia pastoris.
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This is a key step to achieving production at cost and scale appropriate for use worldwide.
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