Calreticulin is a secreted BMP antagonist, expressed in Hensen's node during neural induction

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• 作者：Irene De Almeida^a ; Nidia M.M. Oliveira^a ; Rebecca A. Randall^c ; Caroline S. Hill^c ; John M. McCoy^b ; ¹ ; Claudio D. Stern^a ;
• 关键词：Neural plate ; Gastrulation ; Neurulation ; Chick embryo ; Phospho-Smad ; Calnexin ; Calcium-binding proteins
• 刊名：Developmental Biology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：421
• 期：2
• 页码：161-170
• 全文大小：1306 K
• 卷排序：421

文摘

A functional screen uncovers new secreted factors expressed by chick Hensen's node A yeast Signal Sequence Trap identifies candidates including Calreticulin and Calnexin. We show thatCalreticulin is secretedand binds to BMP4. Calreticulin acts as a BMP antagonist in vivo and in vitro. Calreticulin does not account for all organizer functions but may contribute to its complexity.