A 6MWT index to predict O2 flow correcting exercise induced SpO2 desaturation in ILD
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- 作者：Josuel Ora ; Luigino Calzetta ; Gabriella Pezzuto ; Lucia Senis ; Gregorino Paone ; Alessia Mari ; Silvia Portalone ; Paola Rogliani ; Ermanno Puxeddu ; Cesare Saltini
- 关键词：Interstitial lung disease ; 6-min walk test ; Oxygen therapy ; Exercise testing
- 刊名：Respiratory Medicine
- 出版年：December, 2013
- 年：2013
- 卷：107
- 期：12
- 页码：2014-2021
- 全文大小：701 K
文摘
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Summary
Introduction
Ambulatory oxygen (O2) is prescribed to interstitial lung disease (ILD) patients with mild hypoxemia, breathlessness and dyspnea on exertion. Oxygen titration is generally done with the 6 minute聽walk test (6MWT) to determine the O2 flow preventing oxygen saturation by pulse oximetry (SpO2) from falling below 88%. His study was designed to generate a 6MWT index predicting the O2 flow allowing completion of the 6MWT without oxygen desaturation.Methods
Oxygen titration data from a group of 66 ILD patients and 30 controls, were used to generate the algorithm determining an index (O2-GAP) predicting oxygen flow required to complete a 6MWT without desaturation below 88%. This index was validated in a group of 93 ILD patients.
Results
The O2-GAP index, as obtained from the derivation population, (r2聽=聽0.97, p聽<聽0.001) was shown to correctly predict the oxygen flow required to complete the 6MWT without SpO2 falling below 88% validated in the validation population (r2聽=聽0.842; p聽<聽0.001).
Conclusions
The O2-GAP index appears to be a useful tool to titrate ambulatory O2 with a single 6MWT on room air in ILD patients with breathlessness and dyspnea on exertion.