Mitochondrial gene expression and respiratory enzyme activities in cardiac diseases
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- 作者：Bornstein ; Belé ; n ; Huertas ; Rosa ; Ochoa ; Pilar ; Campos ; Yolanda ; Guillen ; Fernando ; Garesse ; Rafael ; et. al.
- 关键词：Mitochondria ; Oxidative phosphorylation ; Cardiac disease ; COI ; cytochrome c oxidase subunit I ; ND4 ; NADH dehydrogenase subunit 4 ; OXPHOS ; oxidative phosphorylation ; AS ; aortic stenosis with normal transvalvular pressure gradients ; SAS ; aortic stenosis wit
- 刊名：Biochimica et Biophysica Acta (BBA)/Molecular Basis of Disease
- 出版年：1998
- 出版时间：February 27, 1998
- 年：1998
- 卷：1406
- 期：1
- 页码：85-90
- 全文大小：516 K
文摘
Respiratory enzyme activities and steady-state level of two mitochondrial-encoded transcripts were quantified in heart muscle biopsies from patients suffering various types of cardiomyopathies unrelated to mitochondrial primary disorders. We have found that although the mitochondrial DNA copy number and the concentration of COI and ND4 transcripts remain fairly constant, there is an important increase (up to 6-fold) in respiratory enzyme activities affecting to several oxidative phosphorylation complexes. Idiopathic dilated cardiomyopathy shows the greatest increase, followed by ischemic heart and ventricular hypertrophy due to aortic stenosis. The results suggest an energetic compensatory mechanism in the heart muscle, in the absence of mitochondrial proliferation or activation of mitochondrial gene expression.