Potent immunomodulatory activity of a highly selective cannabinoid CB2 agonist on immune cells from healthy subjects and patients with multiple sclerosis

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• 作者：Pasquale Annunziata^a ; ^{annunziata@unisi.it} ; Chiara Cioni^a ; Claudia Mugnaini^b ; Federico Corelli^b
• 关键词：Cannabinoids ; CB2 receptor ; Neuroimmunomodulation ; Multiple sclerosis ; Neuroinflammation
• 刊名：Journal of Neuroimmunology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：303
• 期：Complete
• 页码：66-74
• 全文大小：1037 K
• 卷排序：303

文摘

COR167 inhibits proliferation of normal and MS immune cells. COR167 shifts Th1 towards Th2 phenotype and down-regulates IL-4, IL-5 and Th17 phenotype. COR167 reduces in vitro cell trafficking through human brain endothelium. Cannabinoid CB2 receptor is a pharmacological target to counteract neuroinflammation.