Plasma endothelial microparticles reflect the extent of capillaroscopic alterations and correlate with the severity of skin involvement in systemic sclerosis

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• 作者：Małgorzata Michalska-Jakubus^a ; ^{mjm@poczta.onet.eu} ; Otylia Kowal-Bielecka^b ; ^{otylia.bielecka@gmail.com} ; Vanessa Smith^c ; ^{vanessa.smith@ugent.be} ; Maurizio Cutolo^d ; ^{mcutolo@unige.it} ; Dorota Krasowska^a ; ^{dorota.krasowska@umlub.pl}
• 关键词：SSc ; systemic sclerosis ; lcSSc ; limited cutaneous SSc ; dcSSc ; diffuse cutaneous SSc ; MPs ; microparticles ; EMPs ; endothelial microparticles ; ECs ; endothelial cells ; PRP ; platelet-rich plasma ; PPP ; platelet-poor plasma ; NVC ; nailfold videocapillaroscopy ; mRSS ; modified Rodnan skin thickness score ; FVC ; forced vital capacity ; DLCO ; diffusing capacity of the lungs for carbon monoxide ; ILD ; interstitial lung disease ; DUs ; digital ulcers ; ANA ; antinuclear antibodies ; ACA ; anti-centromere antibodies ; S
• 刊名：Microvascular Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：110
• 期：Complete
• 页码：24-31
• 全文大小：677 K
• 卷排序：110

文摘

EMPs are associated with particular microvascular alterations objectified on NVC. Quantity and phenotype of EMPs might reflect progressive loss of capillaries in SSc. Total EMPs inversely correlate with the severity of skin involvement. Levels of EMPs might be associated with microvascular complications.