Reversal of myofibroblast differentiation: A review

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• 作者：XiaoHong Yang ; Bo Chen ; Tao Liu ; XiaoHong. Chen ; ^{pharsunr@126.com" class="auth_mail}
• 关键词：Capsaicin (PubChem CID ; 1548943) ; S-Nitroso-N-acetylcysteine (PubChem CID ; 10313479)
• 刊名：European Journal of Pharmacology
• 出版年：5 July 2014
• 年：2014
• 卷：734
• 期：Complete
• 页码：83-90
• 全文大小：641 K

文摘

It has long been considered that fibrosis and fibroblast-to-myofibroblast differentiation are irreversible processes. However, recent data obtained indicates that tissue fibrosis and fibroblast-to-myofibroblast differentiation can indeed be reversed, which offers the possibility of a new therapeutic approach for fibrotic disorders. Here, we discuss the origin of the myofibroblasts and different aspects of their differentiation, especially the key mediators and TGF尾-induced signaling pathways. We also report here a few factors involved in myofiroblast dedifferentiation and several compounds which can reverse the established dedifferentiated myofibroblast, as examples that provide the reader a glimpse of the current trends of approach for discovering useful anti-fibrotic drugs.