Metal-free synthesis of indolizines through oxidative CC and CN bond formations of C (sp³) H bonds

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• 作者：N. Naresh Kumar Reddy ; Darapaneni Chandra Mohan ; Subbarayappa Adimurthy ; ^{adimurthy@csmcri.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：2-Pyridyl acetates ; Alkenes ; Alkynes ; Indolizines ; Iodine
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：9 March 2016
• 年：2016
• 卷：57
• 期：10
• 页码：1074-1078
• 全文大小：744 K

文摘

Iodine catalyzed synthesis of indolizine-1-carboxylates through oxidative CC and CN bond formations by the reaction of 2-pyridyl acetates with alkynes and alkenes without metal, oxidant, and base. This procedure is compatible with a broad range of functional groups in both alkynes and alkenes with good yields. The reaction proceeds through a tandem CC bond formation followed by an intramolecular cyclization.