Metal-free one-pot synthesis of quinoline-2,4-carboxylates via a molecular iodine-catalyzed three-component reaction of arylamines, ethyl glyoxylate, and 伪-ketoesters

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• 作者：Guang-Ming Nan ; ^{nanguangming02@sohu.com" class="auth_mail" title="E-mail the corresponding author} ; Wei Liu
• 关键词：Molecular iodine ; Quinoline-2 ; 4-carboxylates ; Three-component ; Tandem reaction
• 刊名：Chinese Chemical Letters
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：26
• 期：10
• 页码：1289-1292
• 全文大小：372 K

文摘

A simple and metal-free method has been developed for the construction of quinoline-2,4-carboxylates under mild conditions via a molecular iodine-catalyzed three-component tandem reaction of arylamines, ethyl glyoxylate, and 伪-ketoesters. The present protocol provides a convenient and attractive approach to various quinoline-2,4-carboxylates in moderate to good yields with excellent functional group tolerance.