DNA-binding, cytotoxicity, cellular uptake, apoptosis and photocleavage studies of Ru(II) complexes
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- 作者：N. Deepikaa ; C. Shobha Devic ; Y. Praveen Kumara ; K. Laxma Reddya ; P. Venkat Reddya ; D. Anil Kumarb ; Surya S. Singhb ; S. Satyanarayanaa ;
- 关键词：7-AAD ; 7-aminoactinomycin D ; phen ; 1 ; 10-phenanthroline ; CT-DNA ; calf thymus DNA ; DAPI ; 4&prime ; 6-diamidino-2-phenylindole dihydrochloride ; DMSO ; dimethyl sulfoxide ; Dppca ; dipyridophenazine-11-carboxylic acid ; dppz ; dipyridophenazine ; ESI&ndash ; MS ; electro spray ionization mass spectrometry ; 7-Br-dppz ; 7-bromodipyrido [3 ; 2-a ; 20 ; 30-c] phenazine ; Bppp ; 11-bromo-pyrido[2&prime ; 3&prime ; 5 ; 6]pyrazino[2 ; 3-f] [1 ; 10]phenanthroline ; GOLD ; genetic optimization for Ligand Docking ; IC50 ; half-maximal
- 刊名：Journal of Photochemistry and Photobiology B: Biology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：160
- 期：Complete
- 页码：142-153
- 全文大小：1837 K
文摘
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Two Ruthenium(II) polypyridyl complexes were synthesized and characterized.
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10">The two complexes interact with CT-DNA via intercalative mode of binding.
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15">Complex 1 shows higher cytotoxic activity than complex 2 toward HeLa, A549 and Du145 cells
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The two complexes effectively induce apoptosis in HeLa cells.