Mitochondrial control of apoptosis through modulation of cardiolipin oxidation in hepatocellular carcinoma: A novel link between oxidative stress and cancer

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• 作者：Huiqin Zhong^a ; ^b ; Mengqing Xiao^a ; ^b ; ^h ; Kamelija Zarkovic^c ; Mingjiang Zhu^a ; Rina Sa^a ; ^b ; Jianhong Lu^a ; ^b ; Yongzhen Tao^a ; Qun Chen^a ; ^b ; Lin Xia^a ; Shuqun Cheng^e ; Georg Waeg^f ; Neven Zarkovic^g ; ¹ ; Huiyong Yin^a ; ^b ; ^d ; ^h ; ¹ ; ^{hyyin@sibs.ac.cn}
• 关键词：Hepatocellular carcinoma ; Oxidative stress ; Cardiolipin ; 4-hydroxy-2-nonenal ; Apoptosis
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：102
• 期：Complete
• 页码：67-76
• 全文大小：1303 K
• 卷排序：102

文摘

Lipidomics identified distinct patterns of mitochondrial CL in human HCC tumor. Tumor tissue has more diverse fatty acids especially saturated fatty acids in CL. Stage-dependent decrease of 4-HNE protein adducts and CL oxidation in HCC tumor. Incubation of liver cancer cells with TLCL restored apoptotic sensitivity.