Bartonella-associated inflammatory cardiomyopathy in a dog

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• 作者：R.A. Santilli ; Dr. Med. Vet. ; PhD^a ; ^{rasantil@tin.it} ; S. Battaia ; Dr. Med. Vet.^b ; M. Perego ; Dr. Med. Vet.^a ; M. Tursi ; Dr. Med. Vet.^c ; E. Grego ; Dr. Med. Vet.^c ; C. Marzufero ; Dr. Med. Vet.^c ; P. Gianella ; Dr. Med. Vet.^c
• 关键词：Myocarditis ; Bundle branch block ; Ventricular arrhythmias
• 刊名：Journal of Veterinary Cardiology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：19
• 期：1
• 页码：74-81
• 全文大小：2167 K
• 卷排序：19

文摘

A 6-year-old, male, mongrel dog was presented for acute onset of dyspnea and cough. At admission, the dog was cachectic and severely depressed. The electrocardiogram showed a sinus rhythm conducted with left bundle truncular branch block and interrupted by frequent multiform ventricular ectopic beats organized in allorhythmias. Thoracic radiographs revealed a marked cardiomegaly with perihilar edema, whereas transthoracic echocardiography revealed a dilated cardiomyopathy with segmental dyskinesis. Furosemide, enalapril, pimobendan, and mexiletine were prescribed, and a Holter was scheduled after resolution of congestive heart failure. Three days later, the dog died suddenly during sleep. Histopathology revealed diffuse myocyte hypertrophy with multifocal hemorrhages, alternating to areas of severe replacement fibrosis and lymphoplasmocytic infiltrates. Immunohystochemistry stains were strongly positive for T-lymphocyte infiltration (CD3) and weakly positive for B-lymphocytes (CD79). Polymerase chain reaction was positive for Bartonella spp. Based on these results, a post-mortem diagnosis of bacterial inflammatory cardiomyopathy was made.