The Association of Estimated Cardiorespiratory Fitness on mortality risk among those with an elevated gamma gap

详细信息    查看全文

• 作者：Meghan K. Edwards^a ; Paul D. Loprinzi^b ; ^{pdloprin@olemiss.edu}
• 关键词：Epidemiology ; Globulin fraction ; Inflammation ; Survival
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：227
• 期：Complete
• 页码：508-510
• 全文大小：197 K
• 卷排序：227

文摘

An elevated (≥ 3.1 g/dl) gamma gap (Total Protein (g/dl) − Albumin (g/dl)) is associated with increased cardiovascular disease risk and risk for all-cause mortality. Cardiorespiratory fitness is associated with reduced mortality risk. The potential protective effects of cardiorespiratory fitness on mortality risk among those with an elevated gamma gap have yet to be investigated, which was the purpose of this study.MethodsData from the 1999–2006 National Health and Nutrition Examination Survey were used (N = 9251 adults 20–85 yrs). Participants were followed through 2011. Cardiorespiratory fitness was estimated from a recently developed algorithm that was derived to estimate cardiorespiratory fitness within the context of predicting mortality risk.ResultsAfter full adjustments among those with an elevated gamma gap, a 1 metabolic equivalent of task (MET) increase in cardiorespiratory fitness was associated with a 24% reduced hazard of all-cause mortality (HR = 0.76; 95% CI: 0.64–0.91; P = 0.003).ConclusionHaving adequate levels of cardiorespiratory fitness may be of critical importance in reducing all-cause mortality risk, particularly among adults with an elevated gamma gap.