Morphine-induced changes in cerebral and cerebellar nitric oxide synthase activity

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• 作者：Leza ; Juan-Carlos ; Lizasoain ; Ignacio ; San-Martí ; n-Clark ; Olivia ; Lorenzo ; Pedro
• 关键词：Morphine ; Nitric oxide (NO) ; Nitric oxide (NO) synthase ; Brain
• 刊名：European Journal of Pharmacology
• 出版年：1995
• 出版时间：October 4, 1995
• 年：1995
• 卷：285
• 期：1
• 页码：95-98
• 全文大小：330 K

文摘

The effect of acute and chronic morphine treatment on nitric oxide (NO) synthase activity (determined by the rate of conversion of [¹⁴C]arginine into [¹⁴C]citrulline) on mouse brain was studied. Acute morphine treatment induced an increase in Ca²⁺-dependent NO synthase in cerebellum. This effect was blocked by coadministration with naloxone. Chronic morphine treatment (by s.c. pellet) also produced an increase in cerebellar NO synthase, with a maximum on the second day of implantation. No significant changes were found in frontal cortex and forebrain during acute or chronic morphine treatment. The relationship between opiate effects and the l-arginine: NO pathway is discussed.