Identification of blood microRNAs associated to Parkinsońs disease

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• 作者：Regina Margis^a ; ^c ; Rog&#xe9 ; rio Margis^b ; ^c ; ^{rogerio.margis@ufrgs.br} ; Carlos R.M. Rieder^a
• 关键词：Parkinson's disease ; MicroRNA ; Neurodegenerative disease ; RT-qPCR ; Molecular marker
• 刊名：Journal of Biotechnology
• 出版年：2011
• 出版时间：20 March 2011
• 年：2011
• 卷：152
• 期：3
• 页码：96-101
• 全文大小：417 K

文摘

The present study demonstrates that blood samples can be used as a source of miRNA identification associated to Parkinson's disease (PD). A set of six differentially expressed microRNAs were identified. They form two groups according to their expression profile in control, non-treated, early-onset and treated Parkinson's disease subjects. While miR-1, miR-22* and miR-29 expression levels allowed to distinguish non-treated PD from healthy subjects, miR-16-2*, miR-26a2* and miR30a differentiated treated from untreated patients. This study is innovative in contributing to the development of effective PD biomarkers.