Building the Class 2 CRISPR-Cas Arsenal

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• 作者：Kevin M. Lewis¹ ; Ailong Ke¹ ; ^{ailong.ke@cornell.edu}
• 关键词：CRISPR ; Cas ; interference ; immunity ; Cas9 ; Cpf1 ; C2c1 ; C2c2 ; C2c3 ; type II
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：65
• 期：3
• 页码：377-379
• 全文大小：729 K
• 卷排序：65

文摘

Adaptation of CRISPR-Cas9 for genome-editing applications has revolutionized biomedical research. New single-component effector CRISPR systems are emerging from the bioinformatics pipeline. How can we best harness their power? Three new studies will no doubt facilitate this transition by generating the C2c1 and C2c2 structure snapshots in different functional states.