Sonodynamic action of hypocrellin B triggers cell apoptoisis of breast cancer cells involving caspase pathway
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- 作者：Yali Jiaa ; b ; Xiaobing Wanga ; Quanhong Liua ; Albert Wingnang Leungb ; Pan Wanga ; b ; wangpan@snnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Chuanshan Xub ; xcshan@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hypocrellin B ; Sonodynamic therapy ; Mitochondrial damage ; Apoptosis ; Caspase pathway ; Breast cancer cells
- 刊名：Ultrasonics
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：73
- 期：Complete
- 页码：154-161
- 全文大小：1747 K
文摘
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HB-SDT suppressed cell viability, potentiated ROS generation in MDA-MB-231 cells.
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HB-SDT damaged the structure and function of mitochondria.
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The apoptotic response was triggered after HB-SDT treatment.
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Caspase pathway was involved in the mechanisms of cell death induced by HB-SDT.