Human airway epithelial cells investigated by atomic force microscopy: A hint to cystic fibrosis epithelial pathology
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- 作者：Maria Lasalviaa ; b ; 1 ; Stefano Castellanic ; 1 ; Palma D&rsquo ; Antonioa ; Giuseppe Pernaa ; b ; Annalucia Carbonec ; Anna Laura Coliaa ; Angela Bruna Maffionea ; Vito Capozzia ; b ; 2 ; Massimo Conesec ; 2 ; massimo.conese@unifg.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Airway epithelial cells ; Atomic force microscopy ; Cystic fibrosis ; Elastic module ; Fluid absorption ; Roughness
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：348
- 期：1
- 页码：46-55
- 全文大小：2089 K
文摘
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CF bronchial epithelial (CFBE) cells show a disorganized actin cytoskeleton.
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CFBE cells present high roughness and low rigidity in the plasmamembrane.
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CFTR overexpression changes morphology and actin organization.
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CFBE cells absorb more apical fluid than wild type bronchial epithelial cells.
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Fluid absorption is increased by disorganization of actin cytoskeleton.