Role of iNOS-NO-cGMP signaling in modulation of inflammatory and myelination processes
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- 作者：Catarina Rapô ; soa ; cataraposa@gmail.com" class="auth_mail ; cataraposa@hotmail.com" class="auth_mail ; Rayana Leal de Almeida Lunab ; rayanaleal@yahoo.com.br" class="auth_mail ; Ana Karolina Santana Nunesb ; nunes.aks@gmail.com" class="auth_mail ; Rodolfo Thomé ; c ; rodolfo.thome@gmail.com" class="auth_mail ; Christina Alves Peixotob ; peixoto.christina@gmail.com" class="auth_mail
- 关键词：Astrocytes ; Microglia ; Adhesion molecules ; Sildenafil ; Oligodendocytes ; Cerebellum
- 刊名：Brain Research Bulletin
- 出版年：May 2014
- 年：2014
- 卷：104
- 期：Complete
- 页码：60-73
- 全文大小：5657 K
文摘
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NO-cGMP pathway has a controversial role in neuroinflammation/demyelinating models.
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Wild type and iNOS−/− mice treated with sildenafil or untreated were used.
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Sildenafil reduced ICAM, VCAM, PKG, sGC in wild type mice.
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The iNOS−/− mice had reduced VCAM, ICAM, GFAP, PKG and sGC, and damaged myelin.
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In iNOS−/−, sildenafil had no anti-inflammatory effect, but improved myelin.