Therapeutic effects of antibiotic drug tigecycline against cervical squamous cell carcinoma by inhibiting Wnt/尾-catenin signaling
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- 作者：Hui Lia ; Shun Jiaoa ; Xin Lib ; Hasina Banuc ; Shreejana Hamalc ; Xianrong Wanga ; Dr.XianRong.Wang@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cervical cancer ; Tigecycline ; Wnt/尾-catenin signaling ; Drug repurposing
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：6 November 2015
- 年：2015
- 卷：467
- 期：1
- 页码：14-20
- 全文大小：1590 K
文摘
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We repurposed the antibiotic drug tigecycline for cervical cancer treatment.
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Tigecycline is effectively against cervical cancer cells in vitro and in vivo.
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Combination of tigecycline and paclitaxel is synergistic in targeting Hela cells.
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Tigecycline acts on Hela cells through inhibiting Wnt/尾-catenin signaling.
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