Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells

详细信息    查看全文

• 作者：Xiaolin Luo¹ ; Rui Liao¹ ; ³ ; ⁵ ; Kaisa L. Hanley² ; Helen He Zhu¹ ; Kirsten N. Malo² ; Carolyn Hernandez⁴ ; Xufu Wei¹ ; ⁵ ; Nissi M. Varki¹ ; Nazilla Alderson¹ ; Catherine Chu² ; Shuangwei Li¹ ; Jia Fan³ ; Rohit Loomba⁴ ; Shuang-Jian Qiu³ ; Gen-Sheng Feng¹ ; ² ; ⁶ ; ^{gfeng@ucsd.edu}
• 关键词：liver tumorigenesis ; non-alcoholic steatohepatitis ; tumor-initiating cells ; tumor suppressor ; PTEN ; Shp2
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：13 December 2016
• 年：2016
• 卷：17
• 期：11
• 页码：2979-2993
• 全文大小：8730 K
• 卷排序：17

文摘

Shp2/Ptpn11 cooperates with Pten to maintain liver homeostasis and functions Dual deletion of Shp2 and Pten induces NASH-driven hepatocarcinogenesis Combined Shp2/Pten deficiencies promote genesis of liver tumor-initiating cells Inhibiting c-Jun suppressed liver cancer without improving NASH