Cognitive changes across the menopause transition: A longitudinal evaluation of the impact of age and ovarian status on spatial memory

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• 作者：Stephanie V. Koebele^a ; ^b ; Sarah E. Mennenga^a ; ^b ; Ryoko Hiroi^a ; ^b ; Alicia M. Quihuis^a ; ^b ; Lauren T. Hewitt^a ; ^b ; Mallori L. Poisson^a ; ^b ; Christina George^c ; Loretta P. Mayer^c ; Cheryl A. Dyer^c ; Leona S. Aiken^a ; Laurence M. Demers^d ; Catherine Carson^a ; ^b ; Heather A. Bimonte-Nelson^a ; ^b ; ^{bimonte.nelson@asu.edu}
• 关键词：Menopause ; Aging ; VCD ; Cognition ; Learning ; Memory ; Hormone ; Ovary
• 刊名：Hormones and Behavior
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：87
• 期：Complete
• 页码：96-114
• 全文大小：2356 K
• 卷排序：87

文摘

Longitudinal assessment of spatial memory in ovary-intact rats during aging VCD transitional menopause model during aging Greater memory impairment early in the transition was seen in young vs old animals. Follicular depletion amplified age-related memory changes later in the transitionAge at menopause transition onset is critical to consider for cognitive aging.