In vitro bioassay investigations of the endocrine disrupting potential of steviol glycosides and their metabolite steviol, components of the natural sweetener Stevia
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- 作者：Maeve Shannona ; Anders Rehfeldb ; c ; d ; Caroline Frizzella ; Christina Livingstonea ; Caoimhe McGonaglea ; Niels E. Skakkebaekb ; d ; Ewa Wielogó ; rskaa ; Lisa Connollya ; l.connolly@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Endocrine disruptors ; In vitro bioassays ; Steviol ; Reproductive disorders ; CatSper ; Stevia
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：427
- 期：Complete
- 页码：65-72
- 全文大小：900 K
文摘
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Potential of Stevia to act as an endocrine disruptor was investigated.
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Metabolite of Stevia, steviol, induced most significant effects.
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Steviol decreased progesterone receptor response in RGA.
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Steviol caused an increase in progesterone production in H295R assay.
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Steviol induced an agonistic response on CatSper, a progesterone receptor of sperm.