Brain tau deposition linked to systemic causes of death in normal elderly

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• 作者：Keith A. Josephs^a ; ^{josephs.keith@mayo.edu} ; Nirubol Tosakulwong^b ; Stephen D. Weigand^b ; Melissa E. Murray^c ; Jennifer L. Whitwell^d ; Joseph E. Parisi^e ; Dennis W. Dickson^c ; Ronald C. Petersen^a
• 关键词：Mortality ; Tau ; Cancer ; Pulmonary disease ; Gastrointestinal disease ; Normal aging
• 刊名：Neurobiology of Aging
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：50
• 期：Complete
• 页码：163-166
• 全文大小：546 K
• 卷排序：50

文摘

The relationship between causes of death and 4 major neurodegenerative brain proteins (beta-amyloid, tau, alpha-synuclein, and the TAR DNA-binding protein of 43 kDa (TDP-43) were assessed in 94 cognitively normal elderly participants that died without a neurodegenerative disease. There was an association between tau and causes of death (p = 0.01). Tau in the brain was associated with a reduced likelihood of dying from systemic cancers (p = 0.046), and with an increased likelihood of dying from pulmonary (p = 0.03) and gastrointestinal (p = 0.049) diseases. There were no associations between beta-amyloid, alpha-synuclein, or TDP-43 and causes of death. Tau deposition in the brain may have a relationship with systemic causes of death, including cancer, in the cognitively normal elderly.