Protective effect of quercetin on homocysteine-induced oxidative stress

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• 作者：Naime &Ccedil ; elik ; M.Sc.^a ; Ayhan Vurmaz ; Ph.D.^b ; Ahmet Kahraman ; Ph.D.^b ; ^{ahmetkah@aku.edu.tr}
• 关键词：Homocysteine ; Quercetin ; Oxidative stress ; Antioxidants
• 刊名：Nutrition
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：33
• 期：Complete
• 页码：291-296
• 全文大小：621 K
• 卷排序：33

文摘

We investigated compared the protective effect of quercetin treatment with homocysteine-induced oxidative stress in rats. Homocysteine increases oxidative stress as reflected by oxidative (malondialdehyde [MDA] and carbonyl levels) and antioxidative parameters (plasma sulphydril [−SH], reduced glutathione [GSH], superoxide dismutase [SOD], and catalase [CAT] levels). Quercetin is also attenuated oxidative stress through antioxidant mechanisms, by decreasing lipid peroxidation (MDA), protein oxidation (carbonyl content), and nonenzymatic (the decreased plasma −SH and GSH levels) and enzymatic (the decreased SOD and CAT activity) mechanisms.