Protective role of hypoxia-inducible factor-1α-dependent CD39 and CD73 in fulminant acute liver failure

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• 作者：Eunyoung Tak^a ; ¹ ; Dong-Hwan Jung^b ; ¹ ; Seok-Hwan Kim^b ; Gil-Chun Park^b ; Dae Young Jun^a ; Jooyoung Lee^a ; Bo-hyun Jung^c ; Varvara A. Kirchner^d ; Shin Hwang^b ; Gi-Won Song^b ; ^{drsong71@amc.seoul.kr} ; Sung-Gyu Lee^b
• 关键词：ALF ; acute liver failure ; HIF-1α ; hypoxia inducible factor-1α ; CD39 ; ecto-5&prime ; -nucleotidase 39 ; CD73 ; ecto-5&prime ; -nucleotidase 73
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：314
• 期：Complete
• 页码：72-81
• 全文大小：1990 K
• 卷排序：314

文摘

HIF-1a is stabilized during acute liver failure Upregulation of CD39 and CD73 following acute liver failure CD39 and CD73 are transcriptionally induced by HIF-1a Deletion of Cd39 and CD73 aggravates murine acute liver failure DMOG treatment induces HIF-1a stabilization, CD39 and CD73 during acute liver failure in WT mice