Functional analysis of membrane-bound complement regulatory protein on T-cell immune response in ginbuna crucian carp
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- 作者：Indriyani Nura ; b ; Nevien K. Abdelkhaleka ; c ; Shiori Motobea ; Ryota Nakamuraa ; Masakazu Tsujikuraa ; Tomonori Somamotoa ; somamoto@agr.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Miki Nakaoa
- 关键词：Membrane-bound complement regulatory protein ; CD46-like protein ; T-cell ; Teleost ; Ginbuna crucian carp ; PHA
- 刊名：Molecular Immunology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：70
- 期：Complete
- 页码：1-7
- 全文大小：1668 K
文摘
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Identification of complement-regulatory membrane protein (Tecrem) in ginbuna carp.
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Tecrem ubiquitously expressed on blood cells including CD8α+ and CD4+ lymphocytes.
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Coculture with anti-Tecrem mAb inhibited proliferation of PHA-stimulated PBL.
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These findings suggest that Tecrem acts as a T-cell moderator.
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Teleost complement system may play a role for linking adaptive and innate immunity.
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