Structure and function of the AAA + ATPase p97/Cdc48p
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- 作者：Di Xiaa ; xiad@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Wai Kwan Tanga ; Yihong Yeb ; yihongy@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：VCP ; valosin-containing protein ; TER ATPase ; transitional endoplasmic reticulum ATPase ; AAA ; + ; ; extended family of ATPases associated with various cellular activities ; ER ; endoplasmic reticulum ; PQC ; protein quality control ; IBMPEF ; Inclusion Body Myopathy associated with Paget's disease of the bone and Frontotemporal Dementia ; ALS ; amyotrophic lateral sclerosis ; EM ; electron microscopy ; ATP ; Adenosine triphosphate ; ADP ; Adenosine diphosphate ; AMP-PNP ; Adenylyl-imidodiphosphate ; ERAD
- 刊名：Gene
- 出版年：2016
- 出版时间：25 May 2016
- 年：2016
- 卷：583
- 期：1
- 页码：64-77
- 全文大小：2027 K
文摘
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p97/Cdc48p participates in various cellular pathways by functioning as a “segregase”.
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Mutations in p97 have been associated with various human diseases.
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Significant progress has been made in obtaining atomic resolution structures of p97 in different conformations.
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Controversy remains as to the mechanism underlying force generation by p97.
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