CDX2 downregulation is associated with poor differentiation and MMR deficiency in colon cancer
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- 作者：J. Olsena ; b ; 1 ; josn@ruc.dk" class="auth_mail" title="E-mail the corresponding author ; S. Eiholmc ; seh@regionsjaelland.dk" class="auth_mail" title="E-mail the corresponding author ; L.T. Kirkebyb ; lenk@regionsjaelland.dk" class="auth_mail" title="E-mail the corresponding author ; M.L.M. Espersena ; e ; mlme@ruc.dk" class="auth_mail" title="E-mail the corresponding author ; P. Jessb ; pjss@regionsjaelland.dk" class="auth_mail" title="E-mail the corresponding author ; I. Gö ; genü ; rb ; d ; igo@regionsjaelland.dk" class="auth_mail" title="E-mail the corresponding author ; J. Olsend ; jolsen@sund.ku.dk" class="auth_mail" title="E-mail the corresponding author ; J.T. Troelsena ; troelsen@ruc.dk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Gastroenterology ; Colon cancer ; CDX2 ; Cancer biomarkers ; Mismatch repair
- 刊名：Experimental and Molecular Pathology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：100
- 期：1
- 页码：59-66
- 全文大小：1197 K
文摘
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We investigate CDX2 expression with both immunohistochemistry and RT-qPCR.
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Low CDX2 expression is associated with right-sided tumors, poor differentiation grade and MMR-deficiency.
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There is a high concordance between the results from immunohistochemistry and RT-qPCR.
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CDX2 expression was not significantly associated with recurrence risk.