MicroRNAs associated with the pathogenesis of multiple sclerosis
详细信息 查看全文
- 作者：Qingrong Huanga ; Bo Xiaoa ; Xinting Maa ; Mingjuan Qua ; Yanmin Lia ; Prakash Nagarkattib ; Mitzi Nagarkattib ; Juhua Zhoua ; juhua.zhou@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：BBB ; blood&ndash ; brain barrier ; BMI1 ; B lymphoma Mo-MLV insertion region 1 homolog ; CAPS-3 ; caspase-3 ; CEBPB ; CCAAT/enhancer-binding protein beta ; CNS ; central nervous system ; EAE ; experimental autoimmune encephalomyelitis ; GA ; Glatiramer acetate ; HIF-1 ; hypoxia inducible factor-1 ; HO-1 ; heme oxygenase 1 ; IGF-1R ; insulin-like growth factor-1 receptor ; ITGB3 ; integrin beta 3 ; miRNA ; microRNA ; MMP9 ; matrix metallopeptidase-9 ; MS ; multiple sclerosis ; MST2 ; mammalian sterile 20-like kinase 2 ; NRP-1
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 June-15 July 2016
- 年：2016
- 卷：295-296
- 期：Complete
- 页码：148-161
- 全文大小：726 K
文摘
- •
Specific patterns of dysregulated mRNAs are presented in immune cells and brain tissues from multiple sclerosis patients.
- •
Specific miRNAs play a critical role in the pathogenesis of multiple sclerosis.
- •
miRNAs may be used as potential biomarkers for diagnosis of MS and therapeutic targets for MS treatment.
- •
miRNAs may potentially be used as prediction markers for the responses to MS treatment.