Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis

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• 作者：Maurizio Cirilli^a ; ¹ ; Oxana Bereshchenko^b ; ^c ; ¹ ; Olga Ermakova^b ; ^{olga.ermakova@cnr.it} ; Claus Nerlov^b ; ^d ; ^{claus.nerlov@imm.ox.ac.uk}
• 关键词：CCAAT/enhancer binding proteins C/EBPa and C/EBPb ; Large scale protein-protein interactions ; Network functional analysis ; DNA repair protein complexes ; RNA metabolism ; Adipogenesis
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1861
• 期：2
• 页码：467-476
• 全文大小：1573 K
• 卷排序：1861

文摘

Proteomic analysis identifies novel CEBPa and CEBPb binding partners. C/EBPa is a component of large complex containing RUVBL1, RUVBL2 and subunits of RFC complex. Enrichment tests detect statistical significant novel pathways associated with C/EPBa and C/EBPb proteomes. Differential annotation analysis of C/EBPa and C/EBPb interactomes shows their functional specificity and redundancy.