External Ca²⁺ regulates polycystin-2 (TRPP2) cation currents in LLC-PK1 renal epithelial cells

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• 作者：Xiao Qing Dai^a ; ¹ ; Paula L. Perez^c ; ¹ ; Gonzalo Soria^b ; Noelia Scarinci^c ; Mariano Smoler^c ; D. Cristian Morsucci^b ; Kunimasa Suzuki^d ; Marí ; a del Rocí ; o Cantero^c ; Horacio F. Cantiello^b ; ^c ; ^{hcantiello@yahoo.com.ar}
• 关键词：TRP channels ; Polycystin-2 ; TRPP2 ; Ca2+ sensing receptor
• 刊名：Experimental Cell Research
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：350
• 期：1
• 页码：50-61
• 全文大小：1520 K
• 卷排序：350

文摘

The renal epithelial cell line LLC-PK1 expresses endogenous plasma membrane PC2. The endogenous PC2 currents are increased by increasing external calcium. Calcium-sensing receptor (CaSR) agonists mimic the effect of high calcium. PC2 siRNA silencing abolishes the external calcium response. A regulatory mechanism links external calcium and PC2 function via activation of CaSR.