A time-course regulatory and kinetic expression study of steroid metabolizing enzymes by calcitriol in primary cultured human placental cells

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• 作者：Nancy Noyola-Martí ; nez^a ; Ali Halhali^a ; Veró ; nica Zaga-Clavellina^b ; Andrea Olmos-Ortiz^a ; Fernando Larrea^a ; David Barrera^a ; ^{barrera1912@gmail.com} ; ^{vidadav@hotmail.com}
• 关键词：Trophoblast ; Calcitriol ; Cytochromes ; Hydroxysteroid dehydrogenases ; Placenta
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：98-105
• 全文大小：1060 K
• 卷排序：167

文摘

Syncytiotrophoblasts shows higher expression of the steroideogenic enzymes than cytotrophoblasts. Short time calcitriol treatment increases the CYP11A1, CYP19A1 and 3β-HSDI expression in human placenta. CYP17A1 and 17β-HSD3 gene are expressed in low levels in human placenta. Calcitriol effects are dependent on the treatment time and the differentiation process of trophoblast cells.