Gemcitabine treatment enhanced the anti-tumor effect of cytokine induced killer cells by depletion of CD4⁺CD25^bri regulatory T cells

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• 作者：Peng Zhao^a ; ¹ ; Danni Zhu^a ; ¹ ; Zhen Zhang^a ; Bin Han^b ; Daiqing Gao^a ; Xiaofang Wei^a ; Xihe Xie^a ; Changyou Li^a ; Weihong Sun^a ; Qingqing Wang^c ; Qingming Guo^a ; ^{qingming_677@163.com}
• 关键词：Gemcitabine cytokine induced killer cells CD4+CD25bri regulatory T cells cytotoxicity
• 刊名：Immunology Letters
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：181
• 期：Complete
• 页码：36-44
• 全文大小：2255 K
• 卷排序：181

文摘

The possible mechanism of enhanced anti-tumor activity of gemcitabine treated CIK cells is that adoptive transfer of CIK cells with CD4+CD25bri regulatory T cells removed can create a strengthened tumor immune microenvironment with the changed level of cytokines.