Divergent regulatory roles of extracellular ATP in the degranulation response of mouse bone marrow-derived mast cells

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• 作者：Kazuki Yoshida ; Masaaki Ito ; Isao Matsuoka ; ^{isao@takasaki-u.ac.jp}
• 关键词：Bone marrow-derived mast cell (BMMC) ; ATP ; P2X7 receptor ; P2X4 receptor ; FcεRI ; Adenosine A3 receptor
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：43
• 期：Complete
• 页码：99-107
• 全文大小：1004 K
• 卷排序：43

文摘

Roles of purinergic signalling in mast cell degranulation were examined. P2X7 receptor activation directly induced mast cell degranulation. ATP potentiated antigen-induced degranulation via P2X4 receptor activation. ATP and its degradation product adenosine synergistically induced degranulation. These purinergic regulations may be crucial for pathophysiological role of mast cells.