Insulin-like growth factor-1 protects SH-SY5Y cells against β-amyloid-induced apoptosis via the PI3K/Akt-Nrf2 pathway

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• 作者：Zigao Wang^a ; ^b ; ¹ ; Lu Xiong^c ; ¹ ; Guanqun Wang^b ; ^d ; Wenbin Wan^a ; Chunjiu Zhong^a ; Hengbing Zu^b ; ^{hbzyy8@sina.com}
• 关键词：IGF-1 ; β-amyloid ; Apoptosis ; Oxidative stress ; PI3K/Akt ; Nrf2
• 刊名：Experimental Gerontology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：87
• 期：part_PA
• 页码：23-32
• 全文大小：1259 K
• 卷排序：87

文摘

IGF-1 inhibited Aβ25–35-induced apoptosis in SH-SY5Y cells. IGF-1 protected against Aβ25–35-induced neurotoxicity by scavenging ROS. PI3K/Akt-Nrf2 signaling pathway was involved in the protective effect of IGF-1.