GAS2L1 Is a Centriole-Associated Protein Required for Centrosome Dynamics and Disjunction

详细信息    查看全文

• 作者：Franco K.C. Au¹ ; ⁴ ; Yue Jia¹ ; ⁴ ; Kai Jiang² ; Ilya Grigoriev² ; Bill K.T. Hau¹ ; Yuehong Shen¹ ; Shengwang Du³ ; Anna Akhmanova² ; Robert Z. Qi¹ ; ⁵ ; ^qirz@ust.hk
• 关键词：centrosome ; centriole ; GAS2L1 ; actin ; microtubules ; plus-end-tracking proteins ; end-binding proteins
• 刊名：Developmental Cell
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：40
• 期：1
• 页码：81-94
• 全文大小：4580 K
• 卷排序：40

文摘

GAS2L1 is a proximal end-localizing protein on mature centrioles GAS2L1 plays an essential role in centriole motility and centrosome disjunction GAS2L1 exerts a centrosome-splitting effect opposing that of the centrosome linker GAS2L1 acts on centrosomes through its association with microtubules and actin