Cerulein-induced pancreatic fibrosis is modulated by Smad7, the major negative regulator of transforming growth factor-β signaling
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- 作者：Xuan Lia ; d ; Salvatore Naniaa ; d ; Nino Fejzibegovica ; Carlos Ferná ; ndez Morob ; Lena Klopp-Schulzed ; Caroline Verbekec ; J.-Matthias Lö ; hra ; d ; Rainer L. Heuchela ; d ; rainer.heuchel@ki.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：Smad7 ; TGFβ ; Chronic pancreatitis ; Fibrosis
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1862
- 期：9
- 页码：1839-1846
- 全文大小：2053 K
文摘
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Smad7 is important for the regulation of TGF-β downstream genes in vivo.
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Smad7 plays a critical regulating role in chronic pancreatitis.
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Lack of a functional Smad7 gene results in more severe damage response in experimental chronic pancreatitis.